Approved Study Database
| Ref. No. | Scientific Title | Principal investigator |
|---|---|---|
| 2011.170 | Psychiatric morbidity in Chinese patients with hepatocellular carcinoma | Dr. CHAN Stephen Lam |
| 2015.581 | A Study of Safety, Tolerability, and Clinical Activity of Durvalumab and Tremelimumab Administered as Monotherapy, or Durvalumab in Combination with Tremelimumab or Bevacizumab in Subjects with Advanced Hepatocellular Carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2017.661 | PHASE 1/2 STUDY OF TAS-120 IN PATIENTS WITH ADVANCED SOLID TUMORS HARBORING FGF/FGFR ABERRATIONS |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2017.049 | A phase Ib study of PDR001 in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC) |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2017.653 | A Phase III, Open-Label, Randomized Study of Atezolizumab in Combination with Bevacizumab Compared with Sorafenib in Patients with Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2016.172 | A phase Ib/II, open-label, multi-center study of INC280 in combination with PDR001 or PDR001 single agent in advanced hepatocellular carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2016.730 | A study on thromboembolism in pancreatic cancer patients |
Dr. CHAN Stephen Lam 陳林 |
| 2017.465 | A clinical trial of pembrolizumab in patients with hepatitis B virus-related hepatocellular carcinoma, with parallel study on baseline and serial change in the immune environment |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2014.404 | A Randomized Phase 2 Study of LY2157299 versus LY2157299 – Sorafenib Combination versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma | Prof. CHAN Stephen Lam |
| 2016.262 | A Phase III Study of Pembrolizumab (MK-3475) vs. Best Supportive Care as Second-Line Therapy in Subjects with Previously Systemically Treated Advanced Hepatocellular Carcinoma (KEYNOTE-240) |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2016.393 | A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of BLU-554 in Patients with Hepatocellular Carcinoma |
Dr. CHAN Stephen Lam 陳林 |
| 2015.072 | A Phase 3, Randomized, Double-blind,Placebo-controlled Study of Gemcitabine and Nab-paclitaxel combined with Momelotinib in Subjects with Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma Preceded by a Dose-finding, Lead-in Phase | Dr. CHAN Stephen Lam |
| 2014.535 | A phase I/II, multicenter, open-label study of oral FGF401 in adult patients with hepatocellular carcinoma or solid malignancies characterized by positive FGFR4 and KLB expression | Prof. CHAN Stephen Lam |
| 2015.361 | Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Ramucirumab and Best Supportive Care (BSC) Versus Placebo and BSC as Second-Line Treatment in Patients With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein (AFP) Following First-Line Therapy With Sorafenib |
Dr. CHAN Stephen Lam 陳林 |
| 2014.526 | A prospective, multicenter, double-randomised, double-blind, 2-parallel groups, phase 3 study to compare as first line therapy efficacy and safety of masitinib in combination with gemcitabine, to gemcitabine in combination with placebo, followed as second line treatment by masitinib in combination with Folfiri 3 versus placebo in combination with Folfiri 3 in the treatment of patients with non resectable locally advanced or metastatic pancreatic cancer | Prof. CHAN Stephen Lam |
| 2016.016 | A phase III, Open-label, Randomized Study of the Combination Therapy with NC-6004 and Gemcitabine versus Gemcitabine Alone in Patients with Locally Advanced or Metastatic Pancreatic Cancer |
Dr. CHAN Stephen Lam 陳林 |
| 2025.184 | A Phase III, Randomised, Open-label, Sponsor-blinded, Multicentre Study of Rilvegostomig in Combination with Bevacizumab with or without Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma (ARTEMIDE-HCC01) | Prof. CHAN Stephen Lam |
| 2024.098 | Establishment of a Hepatocellular Carcinoma Database | Prof. CHAN Stephen Lam |
| 2025.149 | A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD9793, a T cell-engaging Antibody Targeting Glypican-3 (GPC3) in Adult Participants with Advanced or Metastatic Solid Tumours (RHEA-1) | Prof. CHAN Stephen Lam |
| 2024.368 | A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-022, an anti-TIM-3 Monoclonal Antibody, in Patients with Advanced Solid Tumors (AMBER) | Prof. CHAN Stephen Lam |
| 2024.379 | Phase 2 Study of Futibatinib 20 mg and 16 mg in Patients with Advanced Cholangiocarcinoma with FGFR2 Fusions or Rearrangements | Prof. CHAN Stephen Lam |
| 2024.710 | DESTINY-Biliary Tract Cancer-01: A Phase 3 Study of Trastuzumab Deruxtecan (T-DXd) and Rilvegostomig versus Standard-of-Care Gemcitabine, Cisplatin, and Durvalumab for First Line Locally Advanced or Metastatic HER2-expressing Biliary Tract Cancer | Prof. CHAN Stephen Lam |
| 2024.239 | A PHASE I STUDY OF ERY974 IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC HEPATOCELLULAR CARCINOMA | Prof. CHAN Stephen Lam |
| 2025.180 | An Open-label, Multi-center Phase II Study of Durvalumab and Tremelimumab with Lenvatinib as First-line Treatment in Patients with Unresectable Hepatocellular Carcinoma | Prof. CHAN Stephen Lam |
| 2025.306 | A Randomized Phase 2 Study of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma | Prof. CHAN Stephen Lam |
| 2024.253 | A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 193 in Combination With other Therapies in Subjects With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous MTAP-deletion – Master Protocol | Prof. CHAN Stephen Lam |
| 2024.724 | An Open-Label Phase 1/2 Study of WGI-0301 Plus Sorafenib in Patients with Advanced Hepatocellular Carcinoma as Second Line Therapy |
Prof. CHAN Stephen Lam 陳林 |
| 2024.646 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of TPST-1120 in Combination with Atezolizumab plus Bevacizumab Compared with Placebo plus Atezolizumab plus Bevacizumab in Patients with Unresectable or Metastatic Hepatocellular Carcinoma (HCC) Not Previously Treated with Systemic Therapy | Prof. CHAN Stephen Lam |
| 2025.360 | Establishment of New Territories East Cluster Biliary Tract Cancer Database | Prof. CHAN Stephen Lam |
| 2015.090 | Development of clinical model to predict the capecitabine-related toxicity in the Chinese population of colorectal cancer |
Dr. CHAN Stephen L. 陳林 |
| 2016.074 | A proof-of-concept phase II clinical trial on the use everolimus in TSC2-hull/low hepatocellular carcinoma |
Dr. CHAN Stephen L. 陳林 |
| 2017.501 | A MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY OF VARLITINIB PLUS CAPECITABINE VERSUS PLACEBO PLUS CAPECITABINE IN PATIENTS WITH ADVANCED OR METASTATIC BILIARY TRACT CANCER AS SECOND-LINE SYSTEMIC THERAPY |
Dr. CHAN Stephen L. 陳林醫生 |
| 2017.008 | Prospective study on the inflammation environment of hepatocellular carcinoma as signified by the mIBI in patients treated with systemic treatment and immunotherapeutics |
Dr. CHAN Stephen L. 陳林 |
| 2019.150 | A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation (KEYNOTE-937) |
Dr. CHAN Stephen L. 陳林醫生 |
| 2018.396 | A Phase 3, Randomized, Double-blind Study of Adjuvant Nivolumab versus Placebo for Participants with Hepatocellular Carcinoma Who Are at High Risk of Recurrence after Curative Hepatic Resection or Ablation |
Dr. CHAN Stephen L. 陳林醫生 |
| 2022.202 | Real world analysis of sequencing of systemic treatment in hepatocellular carcinoma |
Prof. CHAN Stephen L. 陳林 |
| 2013.237 | A Multicenter, Randomized, Open-Label, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib (E7080) Versus Sorafenib in First-Line Treatment of Subjects With Unresectable Hepatocellular Carcinoma | Dr. CHAN Stephen L. |
| 2014.091 | Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres followed by Gemcitabine plus Cisplatin for Intra-hepatic Cholangiocarcinoma: A Phase II study | Dr. CHAN Stephen L. |
| 2014.071 | Detection and quantification of mutations in KIT or PDGFRA with droplet digital PCR in plasma of patients with Gastrointestinal Stromal Tumor (GIST) | Dr. CHAN Stephen L. |
| 2009.296 | Detection of circulating tumor cells in advanced hepatocellular carcinoma undergoing systemic therapy: a pilot study | Prof. Chan Stephen L. |
| 2009.086 | Prospective Study of Reginal Lymph Node Staging by Endoscopic Ultrasound Guided Biopsy in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization | Dr Chan Stephen L. |
| 2009.441 | Prospective validation of the Chinese University Prognostic Index and Comparison with AJCC TNM, BCLC, CLIP and Okuda's staging system for hepatocellular carcinoma in Asian polulation | Prof. Chan Stephen L. |
| 2009.433 | Evaluation of enlarged regional lymph nodes with endoscopic ultrasound in unresectable hepatocellular carcinoma | Dr Chan Stephen L. |
| 2017.532 | A Randomized, Open-label, Multi-center Phase III Study of Durvalumab and Tremelimumab as First-line Treatment in Patients with advanced Hepatocellular Carcinoma (HIMALAYA) |
Dr. CHAN Stephen 陳林醫生 |
| 2014.103 | The effect of metformin on the outcome of type II diabetic patients with hepatocellular carcinoma | Dr. CHAN Stephen |
| 2024.150 | Establishment of New Territories East Cluster Pancreatic Cancer Database | Prof. CHAN Stephen |
| 2014.598 | Postural stability in elderly with toe deformities: a case-control study | Miss Chan Som Yu |
| 2005.201 | Correlates of Psychological Distress of Patients after Bypass Graft (CABG) Surgery | CHAN SinYi |
| 2019.273 | Development, implementation and evaluation of a clinical practice guideline for care of preterm infants receiving the non-invasive ventilation: A before and after study |
Ms. CHAN Sin Yee 陳倩儀 |
| 2024.172 | Development of virtual reality-enhanced intervention for adults undergoing elective surgery: a qualitative study | Mr. CHAN Sin Lun |
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