Approved Study Database
| Ref. No. | Scientific Title | Principal investigator |
|---|---|---|
| 2026.332 | RASolute 303: A Phase 3 Global, Multicenter, Open-label, Randomized, 3-Arm Study of Daraxonrasib Monotherapy or Daraxonrasib Plus Gemcitabine and Nab-paclitaxel versus Gemcitabine and Nab-paclitaxel as a First-Line Treatment for Patients with Metastatic Pancreatic Adenocarcinoma | Prof. CHAN Stephen Lam |
| 2026.204 | Long-term Evolution of Patients with Hepatocellular Carcinoma Treated with Immunotherapy and Who Achieve Objective Response: The LEO-HCC study | Prof. Chan Stephen Lam |
| 2026.356 | A Randomized, Open-Label, Multicenter, Phase Ib/II Registration Trial to Observe and Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HH-009 Injection in FGF19-Positive Participants with Advanced or Unresectable Hepatocellular Carcinoma (HCC) Who Have Experienced Progressive Disease After Prior Systemic Therapy | Prof. Chan Stephen Lam |
| 2026.180 | A Phase III, multi-center, open-label, randomised, controlled trial of intravenous obrixtamig in combination with carboplatin and etoposide vs. carboplatin and etoposide as first-line therapy in DLL3-positive patients with unresectable locally advanced or metastatic extrapulmonary neuroendocrine carcinomas | Prof. CHAN Stephen Lam |
| 2026.517 | A Phase II, Randomized, Open-label, Multi-center Study of AK104 in Combination with Lenvatinib versus Lenvatinib in Patients with Advanced Hepatocellular Carcinoma Who Have Progressed on Atezolizumab and Bevacizumab | Prof. Chan Stephen Lam |
| 2026.377 | A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Investigator Choice of Chemotherapy (modified FOLFIRINOX or Gemcitabine plus Nab-paclitaxel) with or without Zoldonrasib (RMC-9805) as First-line Treatment in Patients with Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma (RASolute 305) | Prof. Chan Stephen Lam |
| 2026.208 | A Phase I study on systemic administration of FGFR4-Δ targeted CAR-T cells in patients with hepatocellular carcinoma (HCC) |
Prof. CHAN Stephen Lam 陳林教授 |
| 2026.550 | Real-world Clinical Outcomes on Durvalumab with or without Tremelimumab in Patients with Hepatocellular Carcinoma | Prof. Chan Stephen Lam |
| 2026.221 | Thromboprophylaxis among patients with cancer | Prof. Chan Stephen Lam |
| 2011.369 | Validation of prognostic markers in advanced hepatocellular carcinoma and identification of potential serological prognostic markers | Dr. CHAN Stephen Lam |
| 2013.020 | Development of staging system based on circulating inflammatory marker for HCC | Dr. Chan Stephen Lam |
| 2013.019 | Determination of association between serum folate level and toxicity of capecitabine in patients with colorectal cancers: A prospective cohort study | Dr. CHAN Stephen Lam |
| 2012.404 | A study to evaluate the impact of liver stiffness on treatment outcome of hepatocellular carcinoma | Dr. CHAN Stephen Lam |
| 2011.426 | The use of serum interleukin-6 and interleukin-10 in prognostication of advanced hepatocellular carcinoma | Dr. CHAN Stephen Lam |
| 2008.463 | The use of serum hepatitis B viral DNA in prognosticiation of liver cancers undergoing non-surgical therapy | Dr. Chan Stephen Lam |
| 2011.170 | Psychiatric morbidity in Chinese patients with hepatocellular carcinoma | Dr. CHAN Stephen Lam |
| 2011.332 | A Phase 1b, Open-Label, Dose-Escalation Study Evaluating the Safety and Tolerability of EZN-2968, a Hypoxia-Inducible Factor-1 alpha (HIF-1 alpha) mRNA Antagonist, Administered as a Weekly 2-Hour Intravenous Infusion (for 3 Weeks Per 4-Week Cycle) in Adul | Dr. CHAN Stephen Lam |
| 2019.219 | Study on the clinical role of the Albumin-Bilirubin-index (ALBI) in patients treated with lenvatinib or atezolizumab/bevacizumab for hepatocellular carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2019.431 | A Phase 3 Randomized, Double Blind Study of Pembrolizumab Plus Gemcitabine/Cisplatin versus Placebo Plus Gemcitabine/Cisplatin as First-Line Therapy in Participants with Advanced and/or Unresectable Biliary Tract Carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2019.454 | A Randomized, Open-Label, International, Multi-Center, Phase 3 Clinical Study of PD-1 Antibody SHR-1210 Plus Apatinib (Rivoceranib) Mesylate Versus Sorafenib as First-Line Therapy in Subjects with Advanced Hepatocellular Carcinoma (HCC) Who Have Not Previously Received Systemic Therapy |
Dr. CHAN Stephen Lam 陳林 |
| 2019.474 | A PHASE III, MULTICENTER, RANDOMIZED, OPEN-LABEL STUDY OF ATEZOLIZUMAB (ANTI-PD-L1 ANTIBODY) PLUS BEVACIZUMAB VERSUS ACTIVE SURVEILLANCE AS ADJUVANT THERAPY IN PATIENTS WITH HEPATOCELLULAR CARCINOMA AT HIGH RISK OF RECURRENCE AFTER SURGICAL RESECTION OR ABLATION |
Prof. CHAN Stephen Lam 陳林 醫生 |
| 2019.694 | A phase II clinical trial to study the efficacy of cabozantinib in patients with hepatocellular carcinoma refractory to checkpoint inhibitors |
Dr. CHAN Stephen Lam 陳林 |
| 2019.150 | A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation (KEYNOTE-937) |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2017.653 | A Phase III, Open-Label, Randomized Study of Atezolizumab in Combination with Bevacizumab Compared with Sorafenib in Patients with Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2019.096 | A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination with Atezolizumab versus Sorafenib in Subjects with Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2017.661 | PHASE 1/2 STUDY OF TAS-120 IN PATIENTS WITH ADVANCED SOLID TUMORS HARBORING FGF/FGFR ABERRATIONS |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2019.416 | A Phase III Randomized, Double-Blind, Placebo-Controlled, Multi-Regional, International Study of Durvalumab in Combination with Gemcitabine plus Cisplatin versus Placebo in Combination with Gemcitabine plus Cisplatin for Patients with First-Line Advanced Biliary Tract Cancers (TOPAZ-1) | Dr. CHAN Stephen Lam |
| 2019.387 | A Multicenter, Open-label, Phase I/II Dose Escalation and Expansion Clinical Study to Assess the Safety and Efficacy of MGD013 Monotherapy and in Combination with Brivanib Alaninate (ZL-2301) in Patients with Advanced Liver Cancer | Dr. CHAN Stephen Lam |
| 2019.259 | Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination with either Durvalumab Monotherapy or Durvalumab plus Bevacizumab Therapy in Patients with Locoregional Hepatocellular Carcinoma (EMERALD-1) |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2019.555 | A Phase Ia/Ib, Open-Label, Dose-Escalation and Dose-Expansion Study of the Anti-CTLA-4 Monoclonal Antibody CS1002 as Monotherapy and in Combination with Anti-PD-1 Monoclonal Antibody CS1003 in Subjects with Advanced Solid Tumors |
Dr. CHAN Stephen Lam 陳林 |
| 2019.458 | A Randomized, Multi-center, Phase 3 Study of Nivolumab in Combination with Ipilimumab Compared to Sorafenib or Lenvatinib as First-Line Treatment in Participants with Advanced Hepatocellular Carcinoma |
Dr. CHAN Stephen Lam 陳林 |
| 2019.651 | A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Durvalumab Monotherapy or in Combination With Bevacizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (EMERALD-2) |
Dr. CHAN Stephen Lam 陳林 |
| 2019.636 | Targeting and monitoring MDSCs to improve outcomes of radiofrequency ablation in hepatocellular carcinoma |
Dr. CHAN Stephen Lam 陳林醫生 |
| 2011.030 | A multicenter, global, randomized, double-blind study of axitinib plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma following failure of one prior antiangiogenic therapy | Prof. CHAN Stephen Lam |
| 2010.603 | A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled, Trial of AMG 479 or Placebo in Combination with Gemcitabine as First-line Therapy for Metastatic Adenocarcinoma of the Pancreas | Dr Chan Stephen Lam |
| 2013.001 | A Phase II, open label, single arm, multicenter study of INC280 administered orally in adult patients with advanced hepatocellular carcinoma | Prof. CHAN Stephen Lam |
| 2010.283 | The impact of anti-viral therapy on the outcome of patients with hepatitis B-related hepatocellular carcinoma | Prof Chan Stephen Lam |
| 2010.205 | Prospective randomized double-blind placebo controlled trial to assess the role of lamivudine in patients with hepatitis B related-hepatocellular carcinoma not suitable for oncologic therapy due to poor liver function | Prof. Chan Stephen Lam |
| 2013.474 | A Phase 3, Randomized, Double-blind, Controlled Study of Cabozantinib (XL184) vs Placebo in Subjects with Hepatocellular Carcinoma Who Have Received Prior Sorafenib | Dr. CHAN Stephen Lam |
| 2011.524 | A study on the ambulatory management of febrile neutropenia in patients with cancer undergoing cytotoxic chemotherapy | Dr. Chan Stephen Lam |
| 2010.356 | A Multicenter, Randomized, Double-Blind, Phase 3 Study of Ramucirumab (IMC-1121B) Drug Product and Best Supportive Care (BSC) Versus Placebo and BSC as Second-Line Treatment in Patients With Hepatocellular Carcinoma Following First-Line Therapy With Sorafenib | Dr. Chan Stephen Lam |
| 2010.359 | A Phase II Study of Transarterial Chemoembolization and Axitinib for the Treatment of Unresectable Hepatocellular Carcinoma | Prof. CHAN Stephen Lam |
| 2008.479 | A Randomized Phase I/II, Multi-Center, Open-Label Trial of PR104 and Sorafenib in Patients with Advanced Hepatocellular Carcinoma | Dr. Chan Stephen Lam |
| 2014.262 | A Phase 3, Multicenter, Open-label, Randomized Study of nab®-Paclitaxel Plus Gemcitabine versus Gemcitabine Alone as Adjuvant Therapy in Subjects with Surgically Resected Pancreatic Adenocarcinoma | Dr. CHAN Stephen Lam |
| 2013.338 | A phase II trial of PEG-BCT-100 as the second-line therapy following sorafenib in patients with advanced hepatocellular carcinoma | Dr. CHAN Stephen Lam |
| 2021.638 | A Multicountry, Multicentre, Noninterventional, Retrospective Study to Describe the Real-world Management Outcomes in Patients With Unresectable Hepatocellular Carcinoma |
Prof. CHAN Stephen Lam 陳林 |
| 2021.154 | A Phase 2, Randomized, Open-label Study of Relatlimab in Combination with Nivolumab in Participants with Advanced Hepatocellular Carcinoma who are Naive to IO Therapy but Progressed on Tyrosine Kinase Inhibitors (RELATIVITY-073) |
Dr. CHAN Stephen Lam 陳林 |
| 2022.533 | Artificial Intelligence for the Immune Profiling of Hepatocellular Carcinoma (AI-Immune-HCC) |
Prof. CHAN Stephen Lam 陳林教授 |
| 2011.094 | Current medical practice and relationships between medical treatment and cardiovascular indices measured by USCOM (Ultrasonic Cardiac Output Monotor) in patients with poorly controlled hypertension | Dr. Chan Stewart |
| 2011.370 | Noninvasive cardiac output monitoring to optimise therapy for patients with poorly controlled hypertension: a randomised controlled trial | Dr. Chan Stewart |
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